Cannabidiol (CBD) oil has been gaining traction in the medical world for its potential to help with a variety of conditions, including depression and anxiety. While there is still much to learn about the effects of CBD oil, some scientific findings suggest that it could be beneficial for mental health. For example, research has found that CBD can improve the receptors to which serotonin binds, which can significantly reduce depressive symptoms. However, the relationship between cannabis and anxiety is not always consistent.
Some users report that cannabis helps reduce their anxiety, while others report panic and anxiety as side effects. In animal studies, CBD has been found to reduce the beneficial effects of opioids and also reduce heroin-seeking behaviors. The director of the National Institute on Drug Abuse has stated that CBD oil is safe and, recently, the FDA approved the use of CBD oil in children with epilepsy. CBD also acts directly on the cerebral vasculature by inhibiting the expression of the protein nitric oxide synthase, as well as inhibiting calcium transport across membranes.
This could be beneficial for those suffering from opioid use disorder (OUD), as it could help them avoid being associated with the stigma of treatment for OUD. However, it is important to note that CBD products are often mislabeled and some products contain small amounts of THC despite claims that they do not contain THC. Several studies have reported on the efficacy and tolerability of CBD and nabiximoles for moderate to severe cannabis use disorder. Hemp-derived CBD products (with less than 0.3% THC) are federally legal, but are still illegal under some state laws.
There is also limited evidence to support the use of CBD to treat bipolar mania or nabiximoles to treat ADHD. In one study, pretreatment with CBD resulted in less anxiety, cognitive impairment and speech discomfort. The study also found that those taking a 150 mg dose of CBD or a 600 mg dose of CBD maintained lower blood pressure levels in response to stress compared to those taking a placebo. CBD can be found in a variety of products online and in stores, including dietary supplements, baths, beverages, and foods.
The package insert for the FDA-approved form of CBD Epidiolex lists depression and suicidal ideation as possible adverse reactions. Overall, research suggests that CBD may be beneficial for mental health conditions such as depression and anxiety. However, more research is needed to fully understand its effects on mental health.